ea0063gp6 | Adrenal and Neuroendocrine - Tumour | ECE2019
Sarkadi Balazs
, Meszaros Katalin
, Krencz Ildiko
, Zakarias Sara
, Nemeth Kinga
, Barja Gabor
, Sebestyen Anna
, Papay Judit
, Borka Katalin
, Hujber Zoltan
, Toth Miklos
, Igaz Peter
, Chinopoulos Christos
, Patocs Attila
Introduction: The capability of cancer to accommodate to special metabolic circumstances is a hallmark of itÂ’s existence. Pheochromocytoma/paragangliomas (Pheo/PGL) are rare neuroendocrine tumors with strong and specific metabolic phenotype due to mutations of genes encoding succinate dehydrogenase (SDH) subunits. In this study our aim was to evaluate the expression of glutaminase-1 in hereditary Pheo/PGL tissues and to inhibit SDH activity via pharmacological treatments ...